Full Description

Hydrazine, as a potential chloramination disinfection byproduct with a 10sup-6/sup cancer risk level of10 ng/L, is in need of a high performance analytical method for precise and accurate monitoringat trace levels in drinking water. The conventional procedures for hydrazine determination arearduous with off-line extraction and concentration steps and also difficult to reach ppt levels ofdetection. This paper describes a new method for sensitive and selective determination ofhydrazine in aqueous samples, involving derivatization with 2,3-Naphthalene dicarboxaldehyde(NDA) in sodium carbonate buffer, followed by separation and detection based on liquidchromatography coupled with electrospray tandem mass spectrometry (LC-ESI-MS/MS). In thismethod, a small volume (1 ml) of sample was derivatized, and an aliquot was directly injected inan on-line solid phase extraction (SPE-LC-MS/MS) system. A Lowest Concentration MinimumReporting Limit (LCMRL) study was performed to validate the method along with precision andaccuracy assessment from spiked sample recoveries. The LCMRL from 100L injection was5ng/L. The method detection limit (MDL) was 1ng/L, and even 0.1ng/L MDL can be achievedwhen the background contamination is in control. This method eliminates the off-line extractionand concentration step for hydrazine detection and also shows promise for sub-ppt leveldetection in aqueous samples. Hydrazine is stabilized by pre-adding the NDA to sample bottlesto form the derivative in the field. Includes 9 references, tables, figures.

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Edition: Vol. - No. Published: 11/01/2008 Number of Pages: 17File Size: 1 file , 1.1 MB