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On-line solid phase extraction (SPE) was coupled to liquid chromatography with tandemmass spectrometry (LC/MS/MS) to detect 19 compounds from a diverse group ofpharmaceuticals, pesticides, personal care products and steroids at a concentration as low asng Lsup-1/sup in drinking and surface waters was studied. All results displayed a good degree ofreproducibility, with relative standard deviations (RSD) of less than 12 % for allcompounds. Matrix effects were observed for some compounds without exceeding morethan 25%. Method detection limits were in the range of 2 to 25 ng Lsup-1/sup except for estriolwith a value of 50 ng Lsup-1/sup. The recoveries varied from 87 to 110 % in surface waters. Theanalysis of various water samples with the detection and quantification of some of theselected compounds were also reported. This method was preferred over traditional offlineprocedures since it can minimize tedious sample preparation and increasesproductivity. Includes 12 references, tables, figures.

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Edition: Vol. - No. Published: 11/01/2007 Number of Pages: 14File Size: 1 file , 300 KB