AWWA ACE65466

AWWA ACE65466 Low Dose Risks from Bromate: The Relationship between Drinking Water Concentrations and the Actual Dose to Susceptible Organs in Rats and Humans, Pre-systemic Decomposition
Conference Proceeding by American Water Works Association, 06/01/2007

Cotruvo, Joseph A.; Bull, Richard J.

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This powerpoint presentation's research strategy was: to develop Physiologically BasedPharmacokinetic Model to quantify organ dosefrom ingestion and toxic responses at low dose; and,a mechanism of toxic response at low doses.This leads to:re-examination of basis for MCLG; and,revision of risk assessment at low doses. Topics covered include: Pre-systemic Decomposition; the importance of Bromate in Drinking Water to Water Suppliers; Bromate Health Risk Summary; Critical Risk Assessment Issues; Critical Risk Assessment Issues; Why Risk Assessment Matters; Previous Research; Bromate Chemistry and Kinetics; Bromate Research Program Overview; Model of BromateToxicokinetics; Transport and Decomposition in vivo; Where are we now-summary; and, Current Study-April 2007 to January 2009.