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This slide presentation outlines a study on mammalian cell toxicity of emerging drinking water disinfection byproducts (DBP). Objectives of the study include: U.S. Environmental Protection Agency (USEPA) provides ~50 mg samples of synthesized,analytical grade DBP;analyze the direct-acting cytotoxicity and genomicgenotoxicity of the individual DBPs with Chinesehamster ovary (CHO) cells;determine the cytotoxic and genotoxic rank order ofthe DBPs; and, develop a quantitative and comparative DBP toxicitydatabase. Topics outlined include: Impediments to the Development of a Quantitativeand Comparative DBP Toxicity Database; after 32 years, DBPs are still considered emerging contaminants; Solutions to the Impediments for aComparative Toxicology of DBPs; USEPA study titled, "The Occurrence of Disinfection Byproducts (DBPs) of Health Concern in Drinking Water: Results of a Nationwide DBP Study Occurrence Study"; USEPA Stage 2 DBP Rule; alternatives to chlorine disinfection; Emerging DBP Chemical ClassesThat Are Currently Being Analyzed; Chinese Hamster Ovary Cells; Mammalian Cell ChronicCytotoxicity Assay; Cytotoxicity Absorbancy Data:Dibromoacetamide; CHO Cell Cytotoxicityof Haloacetic Acids, Emerging Haloacid DBPs, Halonitromethanes; Summary of DBPs Analyzed withthe CHO Chronic Cytotoxicity Assay; Genomic DNA Damage Induced by DrinkingWater Disinfection Byproducts; SCGE Analysis ofHaloacetic Acids, emerging Haloacids,Halonitromethanes in CHO Cells; and, Comparative DBP Genotoxicity Database. Includes figures.

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Edition: Vol. - No. Published: 06/01/2006 Number of Pages: 44File Size: 1 file , 1.2 MB